[Name of drug]

General name: lincomycin hydrochloride injection

English name: Lincomycin Hydrochloride Injection

Hanyu pinyin: Yansuanlinkemeisu Zhusheye

【 composition 】

Lincomycin hydrochloride is the main component of this product

【 properties 】

This product is a colorless clear liquid

[indications]

This product is suitable for sensitive staphylococcus, streptococcus, streptococcus pneumoniae and respiratory infections, skin and soft tissue infections caused by anaerobic bacteria, infection of female genital tract infection and pelvic and abdominal cavity infection, etc., the latter two diseases according to the situation of the product alone or with other antimicrobials in combination with the application. In addition, patients with application of penicillin indications such as when a patient is allergic to penicillin or unfavorable use this product can be used as an alternative drug penicillin

【 usage and dosage 】

Intramuscular injection: adult one day is 0.6 ~ 1.2 g, children daily according to the weight of 10 ~ 20 mg/kg, injections. Intravenous drip: a general adult 0.6 g, every 8 hours or 12 hours, every 0.6 g dissolved in 100 ~ 200 ml infusion, drip 1 ~ 2 hours. Children daily according to the weight of 10 ~ 20 mg/kg. When must pay attention to the intravenous drip every 0.6 g soluble in not less than 100 ml solution in drip time not less than 1 hour. The baby no less than 4 weeks

[adverse reactions]

1. Gastrointestinal reactions: nausea, vomiting, abdominal pain, diarrhea and other symptoms;Severe cases include abdominal cramps, abdominal tenderness, severe diarrhea (watery or purulent blood), accompanied by fever, abnormal thirst and fatigue (pseudomembranous enteritis).Diarrhea, enteritis, and pseudomembranous enteritis may occur in the early days of administration or several weeks after withdrawal.Blood system: leukopenia, neutropenia, neutropenia and thrombocytopenia may occur occasionally. Aplastic anemia is rare 3.Allergic reactions: rash, pruritus, occasional urticaria, angioneurotic edema, and serum reaction, etc., rare reports of epidermal exfoliation, bullous dermatitis, polymorphic erythema, and s-j syndrome.Occasionally there have been reports of jaundice caused by the use of this product.Hypotension, ecg changes and even cardiac and respiratory arrest may occur when the product is injected rapidly.Intravenous administration may cause thrombophlebitis

【 taboo 】

It is contraindicated in patients with a history of allergy to lincomycin and clindamycin

[notes]

1. May be allergic to clindamycin when allergic to this product.2. Interference with diagnosis: serum alanine aminotransferase and aspartate aminotransferase may be increased after taking the drug.3. Use with caution in the following situations :(1) intestinal disease or past history, especially ulcerative colitis, localized colitis, or antibiotic pun enteritis (this product can cause pseudomembranous enteritis).(2) decreased liver function.(3) severe renal dysfunction.4. Close attention should be paid to the frequency of defecation during medication. If the frequency of defecation increases, attention should be paid to the possibility of pseudomembranous enteritis.5. To prevent the occurrence of acute rheumatic fever, the treatment course of this class of drugs for hemolytic streptococcus infection should be at least 10 days.6. Treatment of pseudomembranous enteritis caused by this product. Patients with mild symptoms may recover after withdrawal of the medicine, and patients with moderate to severe conditions should correct the disorders of water and electrolyte.If there is no obvious improvement after the above treatment, the patient should take metronidazole 250 ~ 500mg orally, 3 times a day.If the recurrence of metronidazole can be re-used orally can still be effective, still ineffective can be converted to vancomycin (or a vancomycin) oral, adult 0.5 ~ 2.0g per day, divided by 3 ~ 4 times.7. Occasionally, it may lead to the overpropagation of insensitive microorganisms or cause secondary infection. In case of secondary infection, appropriate measures should be taken.8. Use with caution if you have a history of asthma or other allergies.9. Regular examination of liver, renal function and blood routine is required for the elderly with a course of treatment.10. Babies younger than 1 month old should not be used.11. The elderly with severe underlying diseases are prone to diarrhea or pseudomembranous enteritis and other adverse reactions, which should be closely observed when taking medicine.

Drug interactions

1.Enhanced neuromuscular blockade of inhaled anesthetics, resulting in skeletal muscle weakness and respiratory depression or paralysis (apnea), should be noted during or after surgery. Treatment with anticholinesterase drugs or calcium salts is expected to be effective 2.And anti-creep antidiarrheal, containing argil antidiarrheal share, this product even after treatment in the course of a few weeks have caused severe watery diarrhoea of pseudo membranous enteritis. Because can make delay in colon endotoxin eduction, resulting in diarrhea and intensified, therefore, anti-creep antidiarrheal shoulds not be pooled. This product with white clay antidiarrheal share, the absorption of the former will be significantly reduced, hence they should not be taken at the same time, need to interval time (at least 2 hours). 3.This product has a neuromuscular blocking effect, and when used in combination with myasthenia gravis, the effect of the latter on skeletal muscle will be weakened. In order to control the symptoms of myasthenia gravis, the dosage of myasthenia gravis should be adjusted when used in combination.Either chloramphenicol or erythromycin can be substituted on the target site, or the combination of the latter with the bacterial ribosome 50S subunit can be inhibited. In vitro tests have shown that lincomycin and erythromycin have antagonistic effects, so lincomycin should not be used in combination with chloramphenicol or erythromycin.In combination with opioid analgesics, the respiratory inhibition of this product and the central respiratory inhibition of opioid may lead to prolonged respiratory inhibition or respiratory paralysis (apnea) due to cumulative phenomena, so the patient must be closely observed or monitored.This product can enhance the effect of neuromuscular blockers. The combination of the two should be avoided.Compatibility with neomycin and kanamycin was contraindicated in the same bottle

[pharmacological effects]

The product of common aerobic gram positive bacteria have higher antimicrobial activity, such as staphylococcus aureus (including resistance to penicillin G), epidermis staphylococcus aureus, beta hemolytic streptococcus, streptococcus viridans and streptococcus pneumoniae. Has good antibacterial effect to anaerobic bacteria including tetanus, diphtheria and gas corynebacteria capsular bacillus, etc. Of enterococcus bacteria genera, neisseria meningitidis, neisseria gonorrhea and h. influenzae gram-negative bacteria and fungi inactive. This product with penicillin, chloramphenicol, cephalosporins and tetracycline, no cross resistance between with large ring lactone class is part of the cross resistance of this product in the five sensitive bacteria ribosomes0S subunit, which prevents the extension of the peptide chain, thus inhibits the protein synthesis of bacterial cells. It is generally a bacteriostatic agent, but at high concentration, it also has bactericidal effect on some bacteria

【 storage 】

Airtight save

Specification: according to C18H34N2O6S, 2ml:0.6g