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Business Type: Trade service
Main Products:Western medicineDisposable medical suppliesPharmaceutical chemicalspharmaceutical intermediateEpidemic prevention materials
ID:2005134019
Medical & Health & Beauty Medicine
MOQ:50000.00 Piece(s)
Artesunate injection Artesunate injectableAnti-malaria
L/CT/TD/PWesstern UnionOthers
– Antimalarial
– Treatment of severe falciparum malaria
– Initial treatment of uncomplicated falciparum malaria, when persistent vomiting precludes oral therapy
– Powder for injection, in 60 mg-vial, with one 1 ml-ampoule of 5% sodium bicarbonate and one 5 mlampoule of 0.9% sodium chloride, for slow IV injection (3 to 5 minutes) or slow IM injection
– Dissolve the powder in the entire volume of 5% sodium bicarbonate and shake the vial until the solution becomes clear. Then, add the 0.9% sodium chloride into the vial:
5 ml of 0.9% sodium chloride to obtain 6 ml of artesunate solution containing 10 mg/ml, for IV injection
2 ml of 0.9% sodium chloride to obtain 3 ml of artesunate solution containing 20 mg/ml, for IM injection
– Child under 20 kg: 3 mg/kg/dose
– Child 20 kg and over and adult: 2.4 mg/kg/dose
– One dose on admission (H0) then 12 hours after admission (H12) then 24 hours after admission (H24) then, once daily.
Administer at least 3 doses parenterally, then, if the patient can tolerate the oral route, change to an artemisinin-based combination (do not use the combination artesunate-mefloquine if the patient developed neurological signs during the acute phase).
Weight | IV injection | IM injection |
|---|---|---|
< 3 kg | 1 ml | 0.5 ml* |
3 to < 4 kg | 1.2 ml | 0.6 ml* |
4 to < 5 kg | 1.5 ml | 0.8 ml* |
5 to < 6 kg | 2 ml | 1 ml |
6 to < 8 kg | 2.5 ml | 1.2 ml |
8 to < 10 kg | 3 ml | 1.5 ml |
10 to < 13 kg | 4 ml | 2 ml |
13 to < 15 kg | 4.5 ml | 2.5 ml |
15 to < 17 kg | 5 ml | 2.5 ml |
17 to < 20 kg | 6 ml | 3 ml |
20 to < 25 kg | 6 ml | 3 ml |
25 to < 29 kg** | 7 ml | 3.5 ml |
29 to < 33 kg | 8 ml | 4 ml |
33 to < 37 kg | 9 ml | 5 ml |
37 to < 41 kg | 10 ml | 5 ml |
41 to < 45 kg | 11 ml | 6 ml |
45 to < 50 kg | 12 ml | 6 ml |
50 to < 55 kg** | 13 ml | 7 ml |
55 to < 62 kg | 15 ml | 8 ml |
62 to < 67 kg | 16 ml | 8 ml |
67 to < 71 kg | 17 ml | 9 ml |
71 to < 76 kg | 18 ml | 9 ml |
76 to 81 kg** | 20 ml | 10 ml |
* Use a 1 ml syringe graduated in 0.01 ml when the dose required is less than 1 ml.
** For patients over 25 kg, a 2nd vial must be prepared to obtain the volume needed, a 3rd vial for patients over 50 kg and a 4th vial for patients over 76 kg.
– May cause: gastrointestinal disturbances, dizziness, headache, fever, muscle and joint pain, pruritus; rarely rash, QT interval prolongation, post-treatment haemolytic anaemia (especially in case of hyperparasitaemia and in young children).
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication
– The solution should be clear, do not use if the solution is cloudy or if a precipitate is present.
– Do not use water for injection for:
reconstitution (only use sodium bicarbonate);
dilution (only use sodium chloride).
– Storage: below 25 °C
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