Amoxicillin +Gentamycin Injection

Properties

This product is a white or off-white crystalline powder with a slight bitter taste.

Therapeutic indications

Antibiotics. Amoxicillin mainly uses for treatment the infections caused by Gram positive and negative bacteria which susceptible to penicillin. It is suitable to cure the diseases in poultry and livestock: fevers, losses of appetite, constipation, be laid up, short of  breath, abdominal breath and so on. To domestic animal's flu, nameless fever, the bacillary dysentery, acute gastroenteritis; pig’s erysipelas, pneumonic plague, piglet’s diarrhea, paratyphoid, sickness from E.coli, Brucella, mycoplasma, leptospirosis; poultry’s cholera, chicken’s dysentery, salpingitis; The cow, pig's mastitis, endometritis, syndrome of milkless also has very good curative effect.

Gastrointestinal and respiratory infections caused by gentamycin sensitive bacteria, like E. coli, Klebsiella, Pasteurella and Salmonella spp., in calves, cattle, goats, sheep and swine.

Cattle: gastrointestinal, respiratory and intramammary infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, diarrhoea, bacterial enteritis, mastitis, metritis and cutaneous abscesses. 
Swine: respiratory and gastrointestinal infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, colibacillosis, diarrhoea, bacterial enteritis and mastitis-metritis-agalactia syndrome (MMA).

Dosage and administration 

For intramuscular administration. The general dosage is 1 ml per 10 kg body weight per day for 3 days. 
Cattle: 30-40ml per animal per day for 3 days
Calves: 10-15ml per animal per day for 3days
Swine: 5-10ml per animal per day for 3days

Piglets: 1-5ml per animal per day for 3days

Contraindications

Do not use in known cases of Hypersensitivity to gentamycin,

hypersensitivity to penicillin or other substances of the beta-lactam group.

Special warnings and precautions for use

(i) Special warnings

Shake well before use.

Keep out of light and reach of children.

(ii) Special precautions for use in animals:

Do not use in rabbits, guinea pigs, hamsters, gerbils or any other small herbivores.

(iii) Special precautions to be taken by the person administering the veterinary medicinal product to animals:

Wash hands after use.

Penicillins and cephalosporins may cause hypersensitivity (allergy) following

injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may

lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to

these substances may occasionally be serious.

1). Do not handle this product if you know you are sensitive or of you have been advised not to work with such preparations.

2). Handle this product with great care to avoid exposure, taking all recommended precautions.

3). If you develop symptoms following exposure such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips, or eyes, or difficulty with breathing are more serious symptoms and require urgent medical attention.

4). Don’t overdose.

5). Do not smoke, drink or eat while handling the product.

Interaction with other medicinal products and other forms of interaction

The bactericidal effect of amoxicillin is neutralized by simultaneous use of bacteriostatic acting pharmaceuticals (macrolides, sulfonamides and tetracyclines).

Concurrent administration of gentamicin and other potentially ototoxic or nephrotoxic drugs should be avoided. Potent diuretics such as etacrynic acid and furosemide are believed to enhance the risk of ototoxicity whilst amphotericin B, cisplatin and ciclosporin are potential enhancers of nephrotoxicity.

 Preclinical safety data 

Serious toxicity is unlikely following large doses of amoxicillin. Acute ingestion of large doses of amoxicillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses. 

Withdrawal period: 

For meat: 30days

For milk: 2days

Storage:

Store in cool dry place, between 4-25℃ and protect from light.