Product information:

Pharmacological action:
Amoxicillin is a semi synthetic broad-spectrum penicillin drug. Its antibacterial spectrum and antibacterial activity are basically the same as ampicillin, but its acid resistance is stronger than ampicillin, and its bactericidal effect is stronger and faster than that of ampicillin, but it can not be used in the treatment of meningitis. The half-life is about 61.3 minutes. Amoxicillin was stable under acidic conditions, and the absorption rate of gastrointestinal tract was 90%, which was more rapid and complete than ampicillin.
Amoxicillin has strong bactericidal effect and strong ability to penetrate cell wall. After oral administration, the lactam group in the drug molecule was hydrolyzed immediately to form peptide bond, which rapidly combined with transpeptidase to inactivate it. The only way for bacteria to synthesize glycopeptides by transpeptidase to construct cell wall was cut off. The bacterial cells rapidly became spherical bodies and broke and dissolved. Finally, the bacterial bodies were ruptured and died due to the loss of cell wall and the continuous infiltration of water. It has strong antibacterial and bactericidal effects on most pathogenic G + bacteria and G-bacteria (including cocci and bacilli). Among them, it has good antibacterial activity against Streptococcus pneumoniae, Streptococcus haemolyticus, aerobic Gram-positive cocci such as penicillinase producing Staphylococcus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and other aerobic gram-negative bacteria, and Helicobacter pylori. Hemodialysis can remove some drugs, but peritoneal dialysis has no effect.

Indication:
Amoxicillin is suitable for the following infections caused by sensitive bacteria (non beta lactamase producing strains)
1. Upper respiratory tract infections such as otitis media, sinusitis, pharyngitis and tonsillitis caused by Streptococcus haemolyticus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae.
2. Urogenital tract infection caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis.
3. Skin and soft tissue infection caused by hemolytic streptococcus, Staphylococcus or Escherichia coli.
4. Acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic streptococcus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae.
5. Acute simple gonorrhea.
6. This product can also be used in the treatment of typhoid, typhoid carrier and leptospirosis; amoxicillin can also be combined with clarithromycin and lansoprazole to eradicate Helicobacter pylori in stomach and duodenum and reduce the recurrence rate of peptic ulcer.

Adverse reactions:
1. Nausea, vomiting, diarrhea and pseudomembranous enteritis.
2. Allergic reactions such as rash, drug fever and asthma.
3. Anemia, thrombocytopenia, eosinophilia, etc.
4. Serum aminotransferase may be slightly increased.
5. Secondary infection caused by Candida or drug-resistant bacteria.
6. The central nervous system symptoms such as excitement, anxiety, insomnia, dizziness and abnormal behavior were occasionally seen.