Amoxicillin Sodium and Clavulanate Potassium for Injection

Naijun Ke (Amoxicillin Sodium and Clavulanate Potassium for Injection)

The synergy of the two makes this product have the advantages of rapid absorption, fast onset, high bioavailability, low residue, safety and efficiency.

 1. Strong antibacterial activity

According to the calculation of amoxicillin sodium, amoxicillin sodium and clavulanate potassium for injection are not resistant to pathogenic Escherichia coli K88, and its minimum inhibitory concentration is 2μg/ml, and the minimum bactericidal concentration is 8μg/ml, both of which are less than injection Use amoxicillin sodium (4μg/ml, 16μg/ml).

2. It takes effect quickly

After pigs are injected intramuscularly with this product (6 mg amoxicillin and 1.5 mg clavulanic acid) per 1 kg of body weight, the blood concentration of amoxicillin reaches its peak value after 0.5 to 1 hour, Cmax is 3.9 mg/L, and the plasma elimination half-life t1/2 is At 0.96 hours, the plasma concentration of clavulanic acid reached its peak after about 0.5 hours, Cmax was 0.42mg/L, and the plasma elimination half-life t1/2 was 0.78 hours.

The peak time of the two is the same (0.5h), and the synergy takes effect quickly!

3. Synergistic effect, not easy to resist

Amoxicillin sodium and potassium clavulanate have a 4:1 synergistic effect to kill bacteria and reduce the resistance of bacteria. This product is currently the strongest antibacterial activity and the most effective injection against drug-resistant bacteria. Its antibacterial activity is more than 49 times that of β-lactam products such as cephalosporins, ampicillin sodium and cloxacillin sodium; it is more than 65 times that of macrolide products; it is antibacterial for common aminoglycosides and quinolone products More than 70 times the effect.