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Business Type: Manufacturer
Main Products:antibodymolecular enzymesELISA KITProteinCRO servicesIVD materials
ID:21121468663
Category: Medical & Health & Beauty Medicine
MOQ:20.00 Other
Synthetic PeptideELA2 GE HLE HNE NE PMN-E SCN1
T/T
| CatalogNo: | A8953 |
| Brand: | ABclonal |
| ProductName: | Neutrophil Elastase (ELANE) Rabbit mAb |
| Gene Symbol: | ELANE |
| Alias: | ELA2, GE, HLE, HNE, NE, PMN-E, SCN1 |
| GeneId: | 1991 |
| Swiss-Prot: | P08246 |
| Routing: | Synthetic Peptide |
| Species: | Human |
| ProteinWeight: | 29kDa |
| ObservedMW: | 30KDa |
| Source: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Neutrophil Elastase (ELANE) |
| AntigenSeq: | |
| CrossReactivity: | Human, Mouse |
| Application: | WB, IHC, IF |
| RecommandDilution: | WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF,1:50 - 1:200 |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
| PositiveSamples: | THP-1,U-937 |
| CelluarLocation: | |
| ResearchArea: | Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Signal Transduction |
| Background: | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016] |
| Note: | Rabbit mab;20191111 第N批待上架;20210730 |
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