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ID:21121768974
Category: Medical & Health & Beauty Medicine
MOQ:20.00 Other
Synthetic PeptideRabbit mAbMonoclonalLFS1P53BCC7
T/T
| CatalogNo: | A16324 |
| Brand: | ABclonal |
| ProductName: | Acetyl-p53-K382 Rabbit mAb |
| Gene Symbol: | TP53 |
| Alias: | BCC7;LFS1;P53;TRP53;p53;TP53;BMFS5 |
| GeneId: | 7157 |
| Swiss-Prot: | P04637 |
| Routing: | Synthetic Peptide |
| Species: | Human |
| ProteinWeight: | 44kDa |
| ObservedMW: | 53kDa |
| Source: | Rabbit |
| Immunogen: | A synthetic acetylated peptide around K382 of human p53 (NP_000537.3). |
| AntigenSeq: | HKKLM |
| CrossReactivity: | Human, Mouse |
| Application: | WB |
| RecommandDilution: | WB,1:500 - 1:2000 |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| PositiveSamples: | HeLa,NIH/3T3 |
| CelluarLocation: | Cytoplasm,Endoplasmic reticulum,Mitochondrion matrix,Nucleus,PML body, |
| ResearchArea: | Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,PI3K-Akt Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Endocrine & Metabolism,AMPK Signaling Pathway,Warburg Effect,Neuroscience,Neurodegenerative Diseases |
| Background: | This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). |
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